In these patients, the clinical signs and symptoms have usually taken place over a span of not more than 26 weeks. In fact, many of them have developed the abnormalities during recent days or months. Very few of these clients have any prior history of liver disease. In any event, it is a deadly medical condition which requires hospitalization in the intensive care unit as well as transplant of that organ as soon as possible [1, 2].
The most common cause of this illness in the United States is drug ingestion whether intentional or not. Specifically, acetaminophen is the agent which leads to the situation in the majority of these cases. Whereas treatment with N-acetylcysteine is very beneficial for the treatment of excessive intake of that agent, many physicians will initiate that therapy regardless of the medication responsible for the illness [1, 2].