There are several reasons for the contention that use of antiretroviral agents will lessen the spread of HIV infection. First, transmission of this disease occurs only through individuals who are HIV seropositive. Second, viral load is the strongest risk factor for spread of it. It is also well-known that these agents will lower HIV RNA levels to undetectable ranges .
In fact, viral loads of less than 1,500 copies per cubic millimeter will carry essentially no risk of transmission . Additionally, there is a great deal of clinical experience with the use of antiretroviral drugs in pregnant women, and mother-to-child transmission, as a result, is uncommon in the United States.