The movie starts with a replay of some scenes in the previous Resident Evil movies, with Alice explaining what they are. Then, we are taken to a fight scene between the Umbrella Corporation’s soldiers and Alice and her friends. But Alice falls into the ocean when she tries to escape the debris of an exploding helicopter.
Then, the director takes us back to when Alice and a girl named Becky were trying to flee from a hoard of zombies. While Alice managed to save Becky by asking her to hide in the closet, Alice’s husband / partner who turned to a zombie caught up with her and kills her.
When she wakes up, Alice finds herself towel-clothed at a security holding cell. While seeking a way out, a woman appears asking her why she turned away against Umbrella. Alice recognizes the woman as Jill Valentine, a former Special Operations Agent who became friends with Alice as seen in Resident Evil: Apocalypse. Jill asks her again, but when she Alice responds by asking where her other friends in the ship are, Jill vanishes and a loud, shrill sound is let out, torturing Alice. This continues for one or two more scenes.
Then, a computer generated voice informs everyone of an unauthorized access to the main computer. The security system is disabled, so the central computer needs to re-boot, which will take exactly one minute. In Alice’s cell, two blocks open, one containing a suit and the other serves as an exit passage. Then, we see Alice clad in a “badass” suit.
When the computer is back on, Jill realizes that Alice has escaped. So she orders all soldiers to be alert and commands the laser killing machine activated. Alice heads towards the exit, and when she’s out, she finds herself in a city that appears to be Tokyo.
Then, we see Alice at what she does best.