As well as the infant from the ship, George and Isabelle had three other children together. One is known for being executed at the age of 67, under the orders of Henry VIII—Margaret Pole. The second was a boy, Edward, who later became Earl of Warwick. The third was named Richard.
It was Richard’s birth that led to Isabelle’s death. Just two months after his birth, Isabelle died either of consumption or childbed fever. Richard died shortly after that and mother and baby were buried together.
George was certain that their deaths were due to poison. Unlike in BBC’s The White Queen, George believed a lady-in-waiting, Ankarette Twynyho was responsible for the death of his wife. She was killed in April 1477 but it was not a legal procedure. The jury used to find her guilty was bullied into this conviction, along with the conviction of John Thursby.
George’s mental state deteriorated from here and the relationship between George and Edward became strained. George asked to marry Charles, Duke of Burgundy’s daughter, Mary, but Edward refused this, fearing George would gain too much power. George started moaning and complaining about Edward and they would talk through messengers who would pass their angry notes to one another.
George was eventually arrested and executed on February 17, 1478. It could have all been avoided had George simply followed his brother’s wishes and stayed out of trouble. Their brother Richard proved the benefit of loyalty but that is another story for another day.