Injinji has made a name for itself as the go-to brand of choice for high-performance toe socks, practically owning the entire market and offering a wide variety of choices from size to color to fabric and other options.
The advantage of toe socks for runners is that because each individual toe is encased in its own protective bubble, the fabric can't move anywhere, preventing it from rubbing back and forth against the skin, thereby eliminating hot spots and blisters. Any friction occurs between the sock and the shoe, so your skin is saved, making blisters all but impossible. It also makes them the best socks for Vibram Five Fingers anywhere to be found.
The design also ensures that any moisture is immediately transported away from the skin, even between the toes, where moisture can easily accumulate and become uncomfortable.
Injinji toe socks can be used with or without an additional sock for extra cushioning, which is advisable if backpacking in heavy boots, as the socks themselves are not intended to provide any cushioning.
Two major types are available, either in Coolmax polyester fabric or merino wool, the latter of which is generally preferable for cooler runs, though popular year-round as well.